Zemimet SR 50/1000 mg is contraindicated in patients with: hypersensitivity to the active substances or to any of the excipients listed in Description, or a history of serious hypersensitivity reactions, i.e., angioedema or anaphylaxis, to another dipeptidyl peptidase-4 (DPP4) inhibitor (see Precautions and Adverse Reactions); any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis); diabetic pre-coma; severe renal failure (eGFR < 30 mL/min/1.73 m2); acute conditions with the potential to alter renal function such as: dehydration, severe infection, shock, intravascular administration of iodinated contrast agents (see Precautions); acute or chronic disease which may cause tissue hypoxia such as: cardiac or respiratory failure, recent myocardial infarction, shock; hepatic impairment; acute alcohol intoxication, alcoholism; serious accidental injury.
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